Friday, October 9, 2026

Events and Aging News ~ October 2026

 


Hi Readers, Many thanks to my colleague and friend, Dr. Harry “Rick” Moody, for providing these resources on aging. He is a visiting lecturer at Fielding University. Check out “Meet the Author” on this website on aging and climate change! https://climateandaging.org/?page_id=1811  

As you may have noticed, I have been absent for a while. I got married in August and was totally consumed with the upcoming wedding, consolidating homes, downsizing, selling property, and moving to New Orleans. Ahead is my next best chapter…. With the surprise ending!  AgeDoc

 

ARE THERE RULES FOR AGING?

                 From Dr. Harry “Rick” Moody:

Maybe there are, but most things about that are written by people who are not old. At 81, I feel that now maybe I can qualify. I’m thinking about Roger Rosenblatt’s who wrote this in “The World is a Room with a Piano Waiting to be Played:”

“The older I get, the more I appreciate the wonders around me. I’m not just talking about nature’s extravagances — zebras, cuttlefish, dragon flies, octopuses, though they do still amaze — but rather the wonder attached to the everyday things a younger me might have not paid much notice to, the happy social interactions, coincidences and surprises that counteract all the sorrows and horrors, and say by their existence, we too are life, maybe most of it. Perhaps the mundane becomes more wondrous as we age partly because we move slower. We are more careful. Each step we take becomes fascinating, an object of exquisite study, not only because the stability of your body rides on it, but also because it takes on a disembodied life of its own.  Age concentrates the mind. The moment you realize you will no longer do something you’ve done all your life. The moment you realize that you will now need to do something you’ve never had to do before. The moment you realize that what used to be will never be the same.”

Roger Rosenblatt wrote More Rules for Aging: Making the Most of Your Ridiculous, Wondrous Life (Turtle Point Press, 2026). Rosenblatt is now 86 years old, so he’s my elder. And he’s qualified to write this.

WHAT IS LATE FREEDOM?

 

Dr. Oliver Sacks, who chose to regard old age as “a time of leisure and freedom, freed from the factitious urgencies of earlier days, free to explore whatever I wish, and to bind the thoughts and feelings of a lifetime together.”

A person can be both wise and unhappy, wise and regretful, and even wise and dubious about the wisdom of growing old.

 

 

MESSAGE FROM RAM DASS

 

This message is from a recently discovered letter from Ram Dass.  “Don’t sell yourself short by thinking you are only your body or your personality, no matter how intriguing and dramatic they may be. For behind them, there lies a more profound part of your true self. Call it ‘spiritual’ or call it ‘higher consciousness’… call it what you will, but… Call it! One of the doorways to that higher self is through the cultivation of your intuitive wisdom. As you learn to listen to and trust your intuition, you will find a quiet place in the heart of your being that is wise and can guide your actions. One of the things it will remind you of is your interconnectedness to all things. And out of that appreciation will spontaneously arise compassion for those who suffer; for the earth, and for all living things.”

Thank you, Ram Dass, no longer with us in this world, but with us in our hearts.

 

 

END OF LIFE JOKE

 

George Burns, when he was nearing 90, refused to sign a contract to appear unless it was up to 5 years in the future. Was he deluded or just make a joke? When asked later in his life how his stand-up act had changed as he approached 100 years old, he wittily replied: "Well, I ask for my applause at the beginning of my act instead of at the end. And I never buy green bananas."

Statistician and demographer Benjamin Gompertz in the 19th century discovered what has become known as Gompertz Law: namely, that after midlife, mortality for humans doubles every 8 years. Do the math and you'll see the point about not buying "Green Bananas."

For more on Gompertz Law, see: Gravity and Levity Link

George Burns lived from 1896 to 1996 and he became a centenarian. He acknowledged that his act became funny because of his wife, Gracie Allen, his lifelong love.

 

 

ITEMS OF INTEREST

 

Narrative: Narrative Matters Interdisciplinary Conference
Call for Papers: “Moving Stories: Migrations, Movements, and Meanings” University College Cork, Ireland (June 7 – 10, 2027)
More details at: https://www.narrativematters.co.uk/
Submission of proposals (250 words) by Dec. 18, 2026. 
Send to narrativematters@ucc.ie

 

Hildegard of Bingen. A 12th century nun gives guidance for aging well:
Welcome to Next Avenue Link

 

Simone de Beauvoir. Her life and work offers many insights on old age:
How to Keep Life from Becoming a Parody of Itself: Simone de Beauvoir on the Art of Growing Older Link

 

 

RECOMMENDED READING

 

FULL ECOLOGY: Repairing our Relationship with the Natural World, by
Mary Clare and Gary Ferguson (Heyday, Berkeley, California, 2021).

 

RESET: Making the Most of the Rest of Your Life, by Helen Hirsh
Spence and Debra Yearwood (T60 Publishing, 2026).

 

AGING REIMAGINED: The Adventures of Later Life, by William Randall
(Cambridge University Press, 2026).

 

 

October 2026 COMING EVENTS

 

CHOOSE JOY (Oct. 6, 2026, 7– 8 pm ET) Choose Joy Masterclass, with Babs Plunkett. Sponsored by Sage-ing International. Details and Registration at:
Choose Joy Link

 

CREATIVE AGING. “The Science of Curiosity, Connection and Well-Being” (Oct. 8, 2026, 12 noon to 1 pm, ET). Artist and instructor Jean Mason shares stories of adults who discovered creative passions later in life. She also explores the science of neuroplasticity behind why creative engagement supports wellbeing. Sponsored by the Encore Network. Details at:
Creative Aging: The Science of Curiosity, Connection and Well-Being Link

 

ECOSYSTEM SUMMIT. Age-Friendly Ecosystem Summit (Oct. 8, 15, 22, and 29, 2026). This 2026 virtual event is sponsored by the George Washington University's Center for Aging, Health and Humanities. Details and registration at:
Ecosystem Summit Link

 

INTRODUCTION TO SAGE-ING (Oct. 13, 2026, 1– 2 pm ET) Introduction to Sage-ing International, with Renee Fogarty. Sponsored by Sage-ing International. Details and Registration at:
Sage-ing Link

 

AGING, UNVARNISHED (Oct. 13, 2026, 7 – 8:30 pm ET) Aging, Unvarnished: A Straight-up Conversation Across Age Groups, with Helen Hirsh Spence. Sponsored by Sage-ing International. Details and Registration at:
Aging Unvarnished Link

 

SACRED VISION (Oct. 14t, 2026, 11am– 12:30 pm ET) Sacred Vision: A Transpersonal Perspective, with David Chernikoff. Sponsored by Sage-ing International. Details and Registration at:
Sacred Vision Link

 

INNER ELDER (Oct. 20, 2026, 1 – 2:30 pm ET). Meeting Your Inner Elder, No Matter Your Age, with Mary M. Clare. Sponsored by Sage-ing International. Details and Registration at:
Meeting Your Inner Elder Link

 

COPING (Oct. 27, 2026, 12 noon – 1:30 pm ET). Coping with Grace, Humor and Wisdom, with Carolyn Aldwin. Sponsored by Sage-ing International. Details and Registration at:
Coping with Grace, Humor, and Wisdom Link

 

DEEPENING THE SAGE WITHIN FOR MEN (Oct. 27, Nov. 3, 10, 17, and Dec. 1, 12 noon– 3 pm ET). Deepening the Sage Within for Men, with Brian Jones and Dennis Stamper. Sponsored by Sage-ing International. Details and Registration at:
DSW for Men Link

 

BOOMER TURNS 80. “A Boomer’s Journey to 80” (Oct. 27, 2026, 12 noon ET)

This month's 4th Tuesday Revolutionize Your Retirement Interview with Experts Series features Vicki Thomas, a writer, a Purpose Prize Winner, a two-time cancer survivor, and the Chief Purpose Officer of My Future Purpose. This group helps people rediscover meaning, reinvention, and community in the second half of life. In January, 2026, Vicki Thomas joined the first wave of Boomers entering their 80’s. As she says, “For the first time, millions are living decades longer and creating one of the greatest untapped resources on earth: experience and wisdom.” Vicki Thomas recently published From Woodstock to Wisdom: A Boomer's Journey to 80. The book documents what aging feels like for the Baby Boomer generation, who have lived through one of history’s most dramatic cultural shifts. As host of the program, in February, 2026, Dori Mintzer also joined the first wave of Boomers entering their 80s. Join for a conversation about this book and some of the experiences of the Boomer generation. Use this link to sign up:
https://revolutionizeretirement.com/events/interviews-with-experts-series-vicki-thomas/ or go to www.revolutionizeretirement.com. This free Zoom interview includes a recording link for all registered participants. Direct questions to Dori Mintzer at dorianmintzer@gmail.com or www.revolutionizeretirement.com

 

COMING HOME (Nov. 2, 2026, 1:00 - 3:00 pm ET) Coming Home to Peace: Forgiveness and the Journey to Wholeness, with Eileen Barker. Sponsored by Sage-ing International. Details and Registration at:
Coming Home to Peace Link

 

How Old Do You Feel?

 

“I’ve heard other seniors say they feel younger inside than their outer shell might suggest. That’s also how I feel. Not old or young, but okay with where I am.”

Peter G. Miller, author and veteran newspaper columnist interviewed by The Oldster

For the interview see: Oldster Link



MORE ITEMS OF INTEREST

 

Positive Aging. Is it possible that most of what we think about aging is
wrong?
See “You Have 30 More Years Than You Think” 

 

Purpose in Later Life. “How to rediscover your purpose later in life”

 

Some Valuable Films about Aging.
https://www.moviesaboutaging.org/
(Visit website with a full collection of free films)
See also “The Gerontological Movies Blog”

 

Initiation into Aging. Margaret Morganroth Gullette, "Crawling the Spirit Canoe, From Initiation Rites to Aging Today," The Long Game, July 27, 2026.  LINK
 See also: https://www.instagram.com/p/DbXBvm8DMY9/

 


Wednesday, June 3, 2026

Why Ultra-Processed Foods Matter for Brain Health and Long Life

 



Why Ultra-Processed Foods Matter: What the Latest Research Says

 

On June 3, 2026, the American Journal of Public Health (AJPH) shared new U.S.-focused research on ultra-processed foods, often called UPFs. This invitation-only presentation about the findings, to be published in the journal’s July 2026 issue, presented scientific evidence of how these foods may affect health and what kinds of public policies could help reduce harm. 

What is an ultra-processed food? Simple operational description presented: “a product you cannot make in your own home.” In simple terms, it is a packaged product made mostly through industrial processing and often contains ingredients you would not typically use in a home kitchen, such as flavorings, colorings, emulsifiers, or other additives. 

Research discussed in the issue suggests that people who eat a lot of ultra-processed foods may consume about 500 more calories a day than people eating minimally processed diets. High intake has also been linked to a greater risk of serious chronic conditions such as obesity, heart disease, diabetes, cancer, and cognitive decline.

About the Event

Speakers included public health researchers and policy experts from universities and institutions such as Harvard, the University of California, San Francisco, the University of Kansas, the University of Sydney, Duke, New York University, the University of North Carolina, and the University of Michigan. This event marked the release of the July 2026 American Journal of Public Health issue focused on ultra-processed foods, including evidence of health risks, industry influence, and possible policy responses.

Main Idea

The overall message was that ultra-processed foods are not just a nutrition issue. Researchers argued that these foods are a major driver of chronic disease, are often heavily marketed by large corporations, and could be addressed through clearer rules, better monitoring, and broader changes to the food system.

Key Takeaways

1.    Many different types of studies point in the same direction: eating more ultra-processed foods is linked to worse health outcomes, including heart disease, obesity, some cancers, mental health problems, and cognitive decline.

 

2.    Ultra-processed foods make up a large share of the American diet. Researchers said they account for about 60% of what adults in the U.S. eat, with even higher levels among children.

 

3.    Some of the reported effects were sizable. In one controlled trial, people eating a high-UPF diet consumed more than 500 extra calories a day on average. Other studies linked high intake to higher risks of heart disease and dementia.

 

4.    Researchers also examined the role of large food companies, including tobacco-owned companies in past decades. They argued that some firms used product design, marketing, and lobbying strategies similar to those used in the tobacco industry.

 

5.    The speakers said there are several policy options available, including clearer food labeling, limits on marketing to children, taxes on certain products, updated dietary guidelines, and public purchasing policies that favor less processed foods.

 

6. Researchers also said public support appears strong for more oversight, including better safety testing and stronger consumer protections.

Dementia / cognitive-health study

•       Study followed >5,000 older Americans for a decade.

•       Top UPF consumers experienced a 58% higher dementia risk; 46% higher mild cognitive impairment risk; and 47% higher risk of either outcome.

•       High intake of minimally processed whole foods were associated with a 41% lower dementia risk

•       Associations persisted after adjusting for income, education, race/ethnicity, lifestyle, and baseline comorbidities.

•       Limitation: The study was an observational model with self-reported diet details from participants, (associations, not causal proof) but biologically plausible and consistent with other evidence from prior studies. 

Internal industry documents and history (tobacco ↔ food)

The U.S. tobacco companies (Philip Morris, RJ Reynolds) invested heavily in developing and marketing food from 1980s through 2000s, creating over 380 UPF brands (Oreos, Tang, Jell-O, Kool-Aid, etc.). One study reviewed over 100 private internal documents showing strategies: brand acquisitions, shared R&D, packaging/processing technology reuse, product-engineering transfer (e.g., “king-size” servings analogous to cigarettes), sensory science, and flavor engineering. Example: Lunchables developed under Philip Morris using cigarette-engineering approaches and behavioral research to target children (toy-like design, play/autonomy cues).

Addiction research & food attribute analytics

Model analyses on a nationally representative sample of >200 common foods found: Over 90% of the top addictive-profile foods were ultra-processed. Rapidly absorbed refined carbohydrates (high glycemic hits) were the strongest predictors of addictive-like responses. Energy-dense combinations of refined carbs and fats (often with flavor additives/emulsifiers) amplify the reward-system reinforcement. Lactose emerged as an independent marker in models (often used in UPF formulations); protein content did not protect against addictive profile. Implication: processing creates multiple simultaneous levers (matrix disruption, refined carbs, fats, additives, flavor libraries) that increase palatability and overconsumption risk.

Litigation and legal strategy as a policy lever

As in cigarette and anti-smoking programs, litigation can break the industry’s obstruction by exposing internal documents via discovery, shifting public opinion, and enabling other branches to act. State attorneys general, city attorneys, and private litigators can define harms, seek remedies, and recover damages — potentially accelerating policy and regulation where legislative/administrative action is stalled. Key legal work is needed to develop novel legal theories, define remedies, coordinate multi-state action, and consider outcomes beyond monetary damages (e.g., injunctive relief, marketing restrictions).

Tuesday, May 5, 2026

Lithium Orotate for Alzheimer’s Prevention

 


Lithium Orotate for Alzheimer’s Prevention

Exploring Strategies for Optimum Cognitive Health

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that impacts millions of people worldwide, leading to memory loss, cognitive decline, and diminished quality of life. According to neurologist Dr. Daniel Press, researchers are focusing on amyloid removal therapies, as AD is a massive health problem. In the United States, there are 61.2 million older adults and six million have been diagnosed with AD, costing $18 billion annually. That number is increasing because there are more people living beyond the age of eighty. As researchers continue to search for effective prevention strategies, lithium orotate has gained attention for its potential to support brain health. Separately, emerging research suggests that reduced lithium orotate availability in the brain may be associated with mild cognitive impairment (MCI) and Alzheimer’s Disease, though whether this relationship is causal in humans is not yet established.

Lithium Orotate: A Trace Mineral with Neuroprotective Properties

What is it? Lithium orotate is thought to enhance lithium’s absorption in the body. Unlike the prescription form, lithium carbonate, used for mood disorders, bipolar, and psychiatric care, lithium orotate is available as a dietary supplement at much lower doses. Recent rodent studies suggest that lithium orotate may promote neurogenesis, protect neurons from damage, and reduce the buildup of amyloid plaques—hallmarks of Alzheimer’s Disease. Although the research is still in its early stages, some findings indicate that low-dose lithium orotate supplementation, 5 mg to 10 mg daily, may help preserve cognitive function and slow disease progression by clearing amyloid plaques and accumulated tau protein in the brain. It is extremely safe and there is no toxicity when taken at these low doses.

What the Evidence Suggests and What it does Not

The idea that “lithium loss ignites Alzheimer’s disease” comes from recent research proposing that naturally occurring lithium in the brain may help support normal brain aging—and that a drop in brain lithium availability could be an early event in Alzheimer’s Disease. In this model, lithium becomes less available partly because it is sequestered (or bound) by amyloid plaques, potentially disrupting protective signaling pathways.

In a 2025 study published in Nature, researchers reported that lithium was the only one of dozens of measured trace metals that was significantly reduced in the prefrontal cortex in people with mild cognitive impairment (MCI) and AD, and that lithium appeared concentrated within amyloid plaques—consistent with the hypothesis that plaques can “trap” lithium and reduce its bioavailability in surrounding brain tissue.

In mouse models, reducing dietary lithium (lowering brain lithium) was associated with increased amyloid-β deposition and tau accumulation, pro-inflammatory activation, synaptic/axonal changes, and faster cognitive decline. However, these findings do NOT prove that low lithium causes Alzheimer’s in humans, nor that over-the-counter lithium orotate supplements prevent dementia. Clinical trials of low-dose lithium orotate in MCI and Alzheimer’s remain limited; a 2026 pilot randomized trial in MCI found the intervention feasible and generally well tolerated, but none of its prespecified primary outcomes met the study’s significance threshold.

References and Further Reading:

Aron, L., Ngian, Z.K., Qiu, C. et al. Lithium deficiency and the onset of Alzheimer’s disease. Nature 645, 712–721 (2025). https://doi.org/10.1038/s41586-025-09335-x

 

Beach, S.R. Lithium orotate: Breakthrough treatment for Alzheimer’s Disease? Psychopharmacology Institute. (Accessed 2026).

 

Dutchen, S. (2025, August 12). Could lithium explain and treat Alzheimer’s Disease? https://hms.harvard.edu/news/could-lithium-explain-treat-alzheimers-disease

 

U.S. Census Bureau. QuickFacts: United States. “Persons 65 years and over, percent”: 18.0% (table PST045224; accessed 2026).

 

 


Friday, February 6, 2026

Sundowning

 



It has been described as feelings of sadness, confusion, agitation, and restlessness. Also, edginess and creepy-crawly skin sensations. Actress and singer Liza Minnelli, who has a history of depression and trauma, described it as “getting the afternoon willies.” All these varied symptoms describe a late-day phenomenon called sundowning. According to the Mayo Clinic, “sundowning syndrome” occurs in late afternoon and continues into the evening, a pattern of behaviors triggered by fading sun as day transitions into night (2026).

Sundowning is not a disease but rather a syndrome or collection of symptoms, with no known cause or cure. According to the Cleveland Clinic (2026), about twenty percent of Alzheimer’s patients experience sundowning. Because the majority of people experiencing sundowning have dementia, the bulk of the research has been conducted as it relates to dementia. However, sundowning is not unique to older adults with cognitive decline. People of all ages have reported sundowning symptoms, especially those who have been diagnosed with depression and/or anxiety. I carefully screened the research on sundowning and became frustrated because the peer-reviewed research focuses on cognitive decline and older adults.

Although I thoroughly scanned the peer-reviewed literature for studies related to sundowning and depression, the overwhelming body of research focused on dementia patients. Therefore, I conclude that harmless non-pharmacological approaches can be applied to everyone experiencing sundowning. Music to the rescue! Musical approaches for addressing sundowning symptoms have been studied extensively as they relate to older adults with moderate to severe dementia. An anecdotal study found that exposure to six-minute nature slide shows combined with music alleviated sundowning symptoms in ten individuals who were assessed before and after exposure. Although the study had a small number of participants, it is noteworthy that all ten individuals experienced improvement (2021).

How to treat sundowning presents a twofold conundrum. First, it is not a disease but rather, a syndrome without cause or treatment. Second, the medical community is not in agreement on how to treat it and alleviate symptoms. Therefore, practitioners have developed a number of effective non-pharmacological interventions including light therapy and environmental modifications. A research study conducted by Lineweaver et al. (2022) at Butler University included 101 participants residing in fifteen long-term care facilities. For eight months, the residents with sundowning symptoms listened to personalized playlists from their younger years. They recorded their sundowning symptoms before and after exposure to their music. The results showed that while listening to their music, they experienced less “confusion, disengagement, unresponsiveness, and restlessness” (p. 1040).

Musical approaches are highly effective, according to several recent studies, especially a form of music reminiscence. This approach is effective for alleviating sundowning by listening to music from the era when they were younger. Boomers listen to the Beatles, Motown, Rolling Stones, or Beach Boys, for example. Gen X might choose Michael Jackson, Madonna, a-Ha, or Nirvana. A former client of mine who experienced sundowning started preparing dinner to alleviate his symptoms. Another client went for a late afternoon walk with his dogs to take his mind off sundowning.

Have you ever viewed the Instagram or Facebook postings of frolicking puppies and kittens? Puppy and kitten videos and pictures are popular because they promote feelings of stillness and tranquility. And who can resist smiling? I can't!!

Gazing at kittens, puppies, nature videos, and listening to favorite tunes from “back in the day” are worth trying. These approaches are non-invasive, fun, and pose no health risks. They are free, there are no side effects, and no pharmacy run. It’s worth trying. More later. AgeDoc

References:

Lineweaver, T. T., Bergeson, T. R., Ward, M. J., Hagen, N. A., Ladd, K., Johnson, H., Braid, D., Ott, M., Hay, D. P., Plewes, J., Hinds, M., LaPradd, M. L., Bolander, H., Vitelli, S., Lain, M., & Brimmer, T. (2022). Nursing Home Residents' Positive Behavioral Responses to Individualized Music Predict Improvements in Sundowning Symptoms After Music Listening. Journal of aging and health, 34(6-8), 1037–1047. https://doi.org/10.1177/08982643221087569

 

Rados, R., Kim, J., Kono, S., & Horton, J. (2021). Nature-Based Video with Music for Individuals Experiencing an Episode of Sundown Syndrome. Journal of long-term care, 294-302. https://doi.org/10.31389/jttc69.

 

Sundowning Syndrome (4/26/22). Retrieved from Sundown Syndrome: Causes, Treatment & Symptoms

 

Thursday, November 27, 2025

Brains ~ Complex and Always Changing

 



Hi Readers, scientists are learning more about the brain, but we have so far to go! I know that people worry about their brain health because I am asked about it every day. Sadly, people are hyper aware of every lost key and fixate on how to improve brain functioning. While there are no “fixes” in this study, it is essential to understand how the brain works and how it changes over the lifespan. A research team headed by Dr. Alexa Mousley at the University of Cambridge recently published their breakthrough findings on brain turning points and development across the lifespan.

 

A recent study in Nature Communications published on November 25, 2025, described five distinct structural eras of brain development and unique organizations or “topologies” can be divided into five categorical eras called “epochs.”  The investigators sought to understand brain organization changes throughout the lifespan. How does the brain change with age? What are the underlying principles of developmental brain changes? Are there points in time when the brain transitions into another phase of change?

 

Although one article described this study as “massive,” it was not, yet it remains noteworthy and groundbreaking. Researchers at the University of Cambridge and the University of Pittsburgh examined 4,216 imaging datasets from patients aged 0-90 years old, and their analysis indicated that human development is complex, non-linear, and divided into five lifespan topological epochs.

Epoch 1: Age 0-9,  “Infancy into Childhood” (p. 6). The topologies or connectivity areas of the brain that work together are refined. Gray and white matter grows.

Epoch 2:  Age 9-32, “Adolescence” (p. 7). During this twenty-three-year period, brain connections strengthen, global integration increases, and white matter grows. The result is refined emotional regulation, executive functioning (plan, organize, establish goals), and enhanced reasoning (decision-making, conclusions, logic). Of the five identified epochs, this is the only one suggesting increased vulnerability for development of mental health disorders. “Age 32 is the strongest topological turning point in the lifespan… with the most directional changes and a large shift in trajectory” (Mousley, 2025, p. 9). In other words, the brain peaks.

Epoch 3: Age 32-66, “Adulthood” (p. 7). During this period of three decades of adulthood, the wiring changes and becomes more compartmentalized. Yes, the brain reorganizes! At the end of this epoch, the brain becomes less efficient.

Epoch 4: Age 66-83, “Early Aging” (p. 7-8). White matter degenerates, and my readers know that brain shrinkage is absolutely normal. The brain networks become more compartmentalized and less integrated.

Epoch 5: Age 83-90, “Late Aging” (P. 8). Brain connectivity weakens further, shifting from global to local functions.

 

What does all this mean and how can this research be applied? According to principal investigator Dr. Alexa Mousley, “This study is the first to identify major phases of brain wiring across a human lifespan. These eras provide important context for what our brains might be best at, or more vulnerable to, at various stages of our lives. It could help us understand why some brains develop differently at key points in life, whether it be learning difficulties in childhood, or dementia in our later years” (Lewsey, F., 2025).

 

All research studies have limitations that impact the extrapolation or application of the findings. Scientists always acknowledge limitations in their studies as a call to action for future studies, and to retain academic humility. First, the study was not sex-stratified. Perhaps future studies can compare male and female brain scans to determine if male and female epochs are similar or dissimilar. Second, they acknowledged that the health status of the patients whose brain scans were used in the study remained unknown. Third, the cross-sectional study design prevents causality (cause and effect).

 

References:

 

Mousley, A., Bethlehem, R.A.I., Yeh, FC. et al. Topological turning points across the human lifespan. Nat Commun 16, 10055 (2025). https://doi.org/10.1038/s41467-025-65974-8

 

Lewsey, F., University of Cambridge, November 25, 2025. Retrieved from https://www.cam.ac.uk/stories/five-ages-human-brain

 

 

 


Events and Aging News ~ October 2026

  Hi Readers, Many thanks to my colleague and friend, Dr. Harry “Rick” Moody, for providing these resources on aging. He is a visiting lectu...